The Jacksonville Jaguars are currently the only winless team in the NFL as they prepare to face the Indianapolis Colts, holding a 2.5-point favorite status despite their struggles this season.

Meanwhile, the Kansas City Chiefs remain unbeaten and are favored against the New Orleans Saints in Monday Night Football. The SportsLine model has been successful with its NFL predictions, showing significant profit for bettors and highlighting Buffalo Bills as a strong pick against the Houston Texans.